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Anti-TIAM1 Antibody Picoband®

Selected Variant

PB10103

Size: 100 µg/Vial

Boster Bio Anti-TIAM1 Antibody Picoband® catalog # PB10103. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

T-cell lymphoma invasion and metastasis-inducing protein 1 is a protein that in humans is encoded by the TIAM1 gene. This gene is mapped to 21q22.11. TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA.

Synonyms

T-lymphoma invasion and metastasis-inducing protein 1; TIAM-1; TIAM1

Gene Name

TIAM1

Gene ID

7074

UniProt

Q13009

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TIAM1, different from the related mouse sequence by five amino acids.

Clonality

Polyclonal

Tissue Specificity

Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Applications

WB

Field of Research

G Protein Signaling, Heterotrimeric G Proteins, Regulators, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. .

References & Citations

1. Entrez Gene: TIAM1 T-cell lymphoma invasion and metastasis 1. 2. Chen H, Antonarakis SE (Nov 1995) . Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1. Genomics 30 (1) : 123–7. 3. Uhlenbrock K, Eberth A, Herbrand U, Daryab N, Stege P, Meier F, Friedl P, Collard JG, Ahmadian MR (Sep 2004) . The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. Journal of Cell Science 117 (Pt 20) : 4863–71.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

177508 MW

Observed Molecular Weight

178 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

T-lymphoma invasion and metastasis-inducing protein 1

Subcellular Location

Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Detected at the boundary between cells with actin-rich protrusions (By similarity) . Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. .

Protein Name

T-lymphoma invasion and metastasis-inducing protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

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