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Anti-alpha 1 Antitrypsin/SERPINA1 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

PB10097-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

SERPINA1 is also known as PI, A1A or AAT. This gene is mapped to 14q32.1. The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.

Synonyms

Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1; Short peptide from AAT; SPAAT; SERPINA1; AAT, PI; PRO0684, PRO2209

Gene Name

SERPINA1

Gene ID

5265

UniProt

P01009

Host

Rabbit

Reactivity

Human, Monkey, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human SERPINA1 recombinant protein (Position: E25-T204) . Human SERPINA1 shares 72.8% amino acid (aa) sequence identity with rat SERPINA1.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Expressed in leukocytes and plasma. .

Applications

Flow Cytometry

Field of Research

Apoptosis, Cancer, Cancer Metabolism, Cardiovascular, Cell Biology, Intracellular, Kinases, Metabolism, Metabolism Processes, Pathways and Processes, Protease Inhibitors, Proteolysis/Ubiquitin, Response To Hypoxia, Serum Proteins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.

References & Citations

1. Alpha 1-antitrypsin therapy mitigated ischemic stroke damage in rats.Moldthan HL, et al. J Stroke Cerebrovasc Dis, 2014 May-Jun. 2. Mixture-based combinatorial libraries from small individual peptide libraries: a case study on 1-antitrypsin deficiency.Chang YP, et al. Molecules, 2014 May 16. 3. Serpin peptidase inhibitor clade A member 1 is a biomarker of poor prognosis in gastric cancer.Kwon CH, et al. Br J Cancer, 2014 Nov 11.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

46737 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Alpha-1-antitrypsin

Subcellular Location

Secreted. Endoplasmic reticulum. The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.

Protein Name

Alpha-1-antitrypsin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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