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Anti-SCTR Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Human secretin receptor (gene name SCTR) is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. The SCTR gene is mapped to chromosome 2q14.1 by fluorescence in situ hybridization.

Synonyms

Secretin receptor; SCT-R; SCTR

Gene Name

SCTR

Gene ID

6344

UniProt

P47872

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SCTR.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.

Applications

Flow Cytometry

Field of Research

G Protein Signaling, Growth Factors/Hormones, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

References & Citations

1. Dong M; Miller LJ (2002) . Molecular pharmacology of the secretin receptor. Recept. Channels 8 (3–4) : 189–200. 2. Chow, B. K.-C. Molecular cloning and functional characterization of a human secretin receptor. Biochem. Biophys. Res. Commun. 212: 204-211, 1995. 3. Mark, H. F. L., Chow, B. K.-C. Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry. Genomics 29: 817-818, 1995.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50207 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Secretin receptor

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Name

Secretin receptor

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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