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Anti-Proteasome 20S alpha 2/PSMA2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Proteasome subunit alpha type-2 is a protein that in humans is encoded by the PSMA2 gene. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.

Synonyms

Proteasome subunit alpha type-2;3.4.25.1; Macropain subunit C3; Multicatalytic endopeptidase complex subunit C3; Proteasome component C3; PSMA2; HC3, PSC3

Gene Name

PSMA2

Gene ID

5683

UniProt

P25787

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human PSMA2, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon.

Applications

Flow Cytometry

Field of Research

Cell Biology, Proteasome, Proteasome / Ubiquitin, Proteolysis/Ubiquitin

Purification

Immunogen affinity purified.

Form

Liquid

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component (s) of the proteasome complex through tyrosine phosphorylation.

References & Citations

1. Groll M, Ditzel L, Löwe J, Stock D, Bochtler M, Bartunik HD, Huber R (Apr 1997) . Structure of 20S proteasome from yeast at 2.4 A resolution. Nature 386 (6624) : 463–71. 2. Tomko RJ, Hochstrasser M (2013) . Molecular architecture and assembly of the eukaryotic proteasome. Annual Review of Biochemistry 82: 415–45.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

25899 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Proteasome subunit alpha type-2

Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, P-body . Colocalizes with TRIM5 in the cytoplasmic bodies. .

Protein Name

Proteasome subunit alpha type-2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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