Anti-ADFP/PLIN2 Antibody Picoband® Fluoro647 Conjugated

Adipose differentiation-related protein, also known as perilipin 2 (PLIN2), ADRP or adipophilin, is a protein which in humans is encoded by the ADFP gene. The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene.

Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Metabolism Processes, Pathways and Processes, Signal Transduction

1. Heid, H. W., Schnolzer, M., Keenan, T. W. Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. Biochem. J. 320: 1025-1030, 1996. 2. Shaw, C. S., Sherlock, M., Stewart, P. M., Wagenmakers, A. J. M.Adipophilin distribution and colocalisation with lipid droplets in skeletal muscle. Histochem. Cell Biol. 131: 575-581, 2009.