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Anti-MPP2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene. Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs) . MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.

Synonyms

MAGUK p55 subfamily member 2; Discs large homolog 2; Protein MPP2; MPP2; DLG2

Gene Name

MPP2

Gene ID

4355

UniProt

Q14168

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human MPP2 recombinant protein (Position: R387-Y576) . Human MPP2 shares 96.8% amino acid (aa) sequence identity with mouse MPP2.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. .

Applications

Flow Cytometry

Field of Research

Adapters, Signal Transduction, Transmembrane

Purification

Immunogen affinity purified.

Form

Liquid

Function

Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity) . .

References & Citations

1. Mazoyer S, Gayther SA, Nagai MA, Smith SA, Dunning A, van Rensburg EJ, Albertsen H, White R, Ponder BA (Dec 1995) . A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A.Genomics 28 (1) : 25–31. 2. Shin BK, Wang H, Yim AM, et al. (2003) . Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J. Biol. Chem.278 (9) : 7607–16.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

64581 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

MAGUK p55 subfamily member 2

Subcellular Location

Membrane; Lipid-anchor. Cell projection, stereocilium . Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity) . Colocalizes with MPP5 in the retina, at the outer limiting membrane (OLM) . Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC) . Colocalizes with NF2 in non- myelin-forming Schwann cells. .

Protein Name

MAGUK p55 subfamily member 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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