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Anti-LRIG3 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

LRIG3 (leucine-rich repeats and Ig-like domains-3) is a 140 kDa type I transmembrane glycoprotein member of the mammalian LRIG glycoprotein family. It shares 46.8% and 54.0% amino acid identity with LRIG1 and LRIG2, respectively, with highest conservation in the extracellular, transmembrane, and membrane-proximal sequences. This gene is mapped to chromosome 12q13.2. LRIG3 may play a role in craniofacial and inner ear morphogenesis during embryonic development. It also may act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1.

Synonyms

Leucine-rich repeats and immunoglobulin-like domains protein 3; LIG-3; LRIG3; LIG3; UNQ287/PRO326/PRO335

Gene Name

LRIG3

Gene ID

121227

UniProt

Q6UXM1

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human LRIG3, different from the related mouse sequence by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. .

Applications

Flow Cytometry

Field of Research

Auditory System, Cancer, Developmental Biology, Embryogenesis, Embryonic Stem Cells, Intracellular, Neuroscience, Sensory System, Stem Cells, Surface Molecules, Tumor Antigens, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity) . .

References & Citations

1. Guo, D., Holmlund, C., Henriksson, R., Hedman, H. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. Genomics 84: 157-165, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

123434 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Leucine-rich repeats and immunoglobulin-like domains protein 3

Subcellular Location

Cell membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Detected in cytoplasmic vesicles when coexpressed with ERBB4. .

Protein Name

Leucine-rich repeats and immunoglobulin-like domains protein 3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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