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Anti-HPRT/HPRT1 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is an enzyme encoded in humans by the HPRT1 gene. The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.

Synonyms

Hypoxanthine-guanine phosphoribosyltransferase; HGPRT; HGPRTase;2.4.2.8; HPRT1; HPRT

Gene Name

HPRT1

Gene ID

3251

UniProt

P00492

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human HPRT recombinant protein (Position: A2-S110) . Human HPRT shares 98.1% and 96.3% amino acid (aa) sequence identity with mouse and rat HPRT, respectively.

Clonality

Polyclonal

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. .

Applications

Flow Cytometry

Field of Research

Cell Biology, DNA/Nucleotides, DNA/RNA, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.

References & Citations

1. Ansari MY, Dikhit MR, Sahoo GC, Das P (Apr 2012) . Comparative modeling of HGPRT enzyme of L. donovani and binding affinities of different analogs of GMP. International Journal of Biological Macromolecules50 (3) : 637–49. 2. Finette BA, Kendall H, Vacek PM (Aug 2002) . Mutational spectral analysis at the HPRT locus in healthy children. Mutation Research 505 (1-2) : 27–41.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

24579 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Hypoxanthine-guanine phosphoribosyltransferase

Subcellular Location

Cytoplasm.

Protein Name

Hypoxanthine-guanine phosphoribosyltransferase

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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