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Anti-GNB1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Guanine nucleotide-binding protein G (I) /G (S) /G (T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene. Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.

Synonyms

Guanine nucleotide-binding protein G (I) /G (S) /G (T) subunit beta-1; Transducin beta chain 1; GNB1

Gene Name

GNB1

Gene ID

2782

UniProt

P62873

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human GNB1, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.

Applications

Flow Cytometry

Field of Research

Cancer, Cancer Metabolism, Energy Transfer Pathways, G Protein Signaling, Heterotrimeric G Proteins, Integration Of Energy, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

References & Citations

1. Codina J, Stengel D, Woo SL, Birnbaumer L (1986) . Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical. FEBS Lett. 207 (2) : 187–92. 2. Yan K, Kalyanaraman V, Gautam N (March 1996) . Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. J. Biol. Chem. 271 (12) : 7141–6.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

37377 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Guanine nucleotide-binding protein G (I) /G (S) /G (T) subunit beta-1

Subcellular Location

Cytoplasm, cell cortex . Cytoplasm, myofibril, sarcomere, Z line . Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity) . .

Protein Name

Guanine nucleotide-binding protein G (I) /G (S) /G (T) subunit beta-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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