Anti-FHL3 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene. The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms
Four and a half LIM domains protein 3; FHL-3; Skeletal muscle LIM-protein 2; SLIM-2; FHL3; SLIM2
Gene Name
FHL3
Gene ID
2275
UniProt
Q13643
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human FHL3, identical to the related mouse sequence.
Clonality
Polyclonal
Tissue Specificity
Expressed only in skeletal muscle.
Applications
Flow Cytometry
Field of Research
Cell Biology, Cell Cycle, Cell Differentiation, Cell Type Markers, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Tags & Cell Markers, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression) . Activity requires the presence of KLB. .
References & Citations
1. Entrez Gene: FHL3 four and a half LIM domains 3. 2. Lee SM, Tsui SK, Chan KK, Kotaka M, Li HY, Chim SS, Waye MM, Fung KP, Lee CY (May 1999) . Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1. Somat Cell Mol Genet 24 (3) : 197–202. 3. Morgan MJ, Madgwick AJ (October 1996) . Slim defines a novel family of LIM-proteins expressed in skeletal muscle. Biochem Biophys Res Commun 225 (2) : 632–8.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
31192 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Four and a half LIM domains protein 3
Subcellular Location
Secreted .
Protein Name
Four and a half LIM domains protein 3
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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