Anti-Fgf19 (Fgf15) Antibody

FGF15/19 refers to two orthologous fibroblast growth factors which share 50% aminoacid identity and have similar functions. FGF15 was described in the mouse; FGF19 was found in humans and other species. They share physiological functions and so are often referred to as FGF15/19 or as FGF15/FGF19. They were first described in developing fetal brain. They are now known to be produced in the ileum, and under certain circumstances in the liver and biliary tree. It is thought their principal function is in response to bile acid absorption occurring after meals. FGF15 and FGF19 have similar roles in regulating bile acid synthesis and also glucose metabolism in the liver.

E. coli-derived rat Fgf19 (Fgf15) recombinant protein (Position: R26-K218) . Rat Fgf19 (Fgf15) shares 53.2% and 96.4% amino acid (aa) sequence identity with human and mouse FGF19, respectively.

Cancer, Growth Factors, Growth Factors/Hormones, Neurogenesis, Neurology Process, Neuroscience, Secreted, Signal Transduction, Signaling Pathways, Stem Cells

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. .

1. Jones, SA (2012) . Physiology of FGF15/19. Advances in Experimental Medicine and Biology. 728: 171–82. 2. Potthoff, MJ; Kliewer, SA; Mangelsdorf, DJ (2012) . Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes & Development. 26 (4) : 312–324. 3. Owen, BM; Mangelsdorf, DJ; Kliewer, SA (January 2015) . Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21. Trends in Endocrinology and Metabolism. 26 (1) : 22–9.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.