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Anti-BMP15 Antibody Picoband® Fluoro550 Conjugated

Selected Variant

PB10048-Fluoro550

Size: 100 µg/Vial

Product Specifications

Background

Bone morphogenetic protein 15 is a protein that in humans is encoded by the BMP15 gene. It's mainly involved in folliculogenesis. The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Defects in this gene are the cause of ovarian dysgenesis 2.

Synonyms

Bone morphogenetic protein 15; BMP-15; Growth/differentiation factor 9B; GDF-9B; BMP15; GDF9B

Gene Name

BMP15

Gene ID

9210

UniProt

O95972

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human BMP15 recombinant protein (Position: Q268-R392) . Human BMP15 shares 69.6% amino acid (aa) sequence identity with mouse BMP15.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Widespread in normal smooth muscle tissue and neurons. .

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cardiovascular, Developmental Biology, Germ Cell Markers, Germline Stem Cells, Growth Factors, Growth Factors/Hormones, Reproduction, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, TGF Beta

Purification

Immunogen affinity purified.

Form

Liquid

Function

May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. .

References & Citations

1. Dube JL, Wang P, Elvin J, Lyons KM, Celeste AJ, Matzuk MM (Feb 1999) . The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol Endocrinol 12 (12) : 1809–17. 2. Persani, L.; Rossetti, R.; Di Pasquale, E.; Cacciatore, C.; Fabre, S. (2014) . The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders. Human Reproduction Update 20 (6) : 869–883.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

45055 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Bone morphogenetic protein 15

Subcellular Location

Secreted.

Protein Name

Bone morphogenetic protein 15

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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