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Anti-BDKRB2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Bradykinin receptor B2 is a G-protein coupled receptor forbradykinin, encoded by the BDKRB2 gene in humans. This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein.

Synonyms

B2 bradykinin receptor; B2R; BK-2 receptor; BDKRB2; BKR2

Gene Name

BDKRB2

Gene ID

624

UniProt

P30411

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human BDKRB2, different from the related mouse sequence by five amino acids, and from the related rat sequence by seven amino acids.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Widespread in normal smooth muscle tissue and neurons. .

Applications

Flow Cytometry

Field of Research

Cardiovascular, Vasculature

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

References & Citations

1. Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH (2001) . Potentiation of bradykinin by angiotensin- (1-7) on arterioles of spontaneously hypertensive rats studied in vivo.Hypertension 37 (2 Part 2) : 703–9. 2. Hess JF, Borkowski JA, Young GS, et al. (1992) . Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor.. Biochem. Biophys. Res. Commun. 184 (1) : 260–8.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

45 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

B2 bradykinin receptor

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Name

B2 bradykinin receptor

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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