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Anti-ARHGEF1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Synonyms

Rho guanine nucleotide exchange factor 1;115 kDa guanine nucleotide exchange factor; p115-RhoGEF; p115RhoGEF; Sub1.5; ARHGEF1

Gene Name

ARHGEF1

Gene ID

9138

UniProt

Q92888

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human ARHGEF1, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. .

Applications

Flow Cytometry

Field of Research

Signal Transduction, Signaling Pathway, G Protein Signaling, Regulators, Small G Proteins

Purification

Immunogen affinity purified.

Form

Liquid

Function

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. .

References & Citations

1. Aasheim HC, Pedeutour F, Smeland EB (May 1997) . Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues. Oncogene 14 (14) : 1747–52. 2. Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, Bollag G (Nov 1996) . Identification of a novel guanine nucleotide exchange factor for the Rho GTPase. J Biol Chem 271 (41) : 25452–8.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

102435 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Rho guanine nucleotide exchange factor 1

Subcellular Location

Cytoplasm . Membrane . Translocated to the membrane by activated GNA13 or LPA stimulation.

Protein Name

Rho guanine nucleotide exchange factor 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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