Anti-Apolipoprotein B/APOB Antibody Picoband® Fluoro488 Conjugated

Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.

E. coli-derived human Apolipoprotein B recombinant protein (Position: Q246-N450) . Human Apolipoprotein B shares 82.4% and 80.5% amino acid (aa) sequence identity with mouse and rat Apolipoprotein B, respectively.

Atherosclerosis, Cancer, Cancer Metabolism, Cardiovascular, Cholesterol Metabolism, Heart Disease, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Signal Transduction

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100) . Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

1. Jacobson TA (2011) . Opening a new lipid apo-thecary: incorporating apolipoproteins as potential risk factors and treatment targets to reduce cardiovascular risk. Mayo Clinic Proceedings 86 (8) : 762–780. 2. Lim JS, Lee DH, Park JY, Jin SH, Jacobs DR (2011) . Reliability of low-absorbance lipoprotein cholesterol, non-high-absorbance lipoprotein cholesterol, and apolipoprotein B measurement.Journal of Clinical Lipidology 5 (4) : 264–272.