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Anti-APC2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

APC2, which is also called APCL, is a deduced 2,303-amino acid protein that contains an N-terminal coiled-coil domain, followed by an armadillo domain and five 20-amino acid repeats. The human APC2 gene is mapped to chromosome 19p13.3. It is found that the 20-amino acid repeat domain of APCL could bind beta-catenin (CTNNB1) and deplete the intracellular beta-catenin pool. A reporter gene assay revealed that APCL could regulate interaction of beta-catenin with T cell-specific transcription factors (TCF7), although less efficiently than APC.

Synonyms

Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APC-like; APC2; APCL

Gene Name

APC2

Gene ID

10297

UniProt

O95996

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human APC2, different from the related mouse sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed (at protein level) . Specifically expressed in the CNS. .

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Division, Proteasome / Ubiquitin, Proteolysis/Ubiquitin

Purification

Immunogen affinity purified.

Form

Liquid

Function

Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling. .

References & Citations

1. Nakagawa, H., Murata, Y., Koyama, K., Fujiyama, A., Miyoshi, Y., Monden, M., Akiyama, T., Nakamura, Y. Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin. Cancer Res. 58: 5176-5181, 1998. 2. van Es, J. H., Kirkpatrick, C., van de Wetering, M., Molenaar, M., Miles, A., Kuipers, J., Destree, O., Peifer, M., Clevers, H.Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Curr. Biol. 9: 105-108, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

243949 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Adenomatous polyposis coli protein 2

Subcellular Location

Cytoplasm, cytoskeleton . Golgi apparatus . Cytoplasm . Cytoplasm, perinuclear region . Associated with actin filaments (PubMed:11691822) . Associated with microtubule network (PubMed:10644998, PubMed:11691822) . .

Protein Name

Adenomatous polyposis coli protein 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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