Anti-ALDH1B1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Aldehyde dehydrogenase X, mitochondrial is an enzyme that in humans is encoded by the ALDH1B1 gene. This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems.
Synonyms
Aldehyde dehydrogenase X, mitochondrial;1.2.1.3; Aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1; ALDH1B1; ALDH5, ALDHX
Gene Name
ALDH1B1
Gene ID
219
UniProt
P30837
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human ALDH1B1, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
Clonality
Polyclonal
Tissue Specificity
Liver, testis and to a lesser extent in brain.
Applications
Flow Cytometry
Field of Research
Cancer, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
References & Citations
1. Dolgin E (Jun 2011) . Mouse library set to be knockout. Nature 474 (7351) : 262–3. 2. Hsu LC, Chang WC (Jul 1991) . Cloning and characterization of a new functional human aldehyde dehydrogenase gene. The Journal of Biological Chemistry266 (19) : 12257–65.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
57206 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Aldehyde dehydrogenase X, mitochondrial
Subcellular Location
Mitochondrion matrix.
Protein Name
Aldehyde dehydrogenase X, mitochondrial
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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