Anti-AKR1C1/C2 Antibody Picoband®

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. And this gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.

Aldo-keto reductase family 1 member C2;1.-.-.-;3-alpha-HSD3; Chlordecone reductase homolog HAKRD; Dihydrodiol dehydrogenase 2; DD-2; DD2; Dihydrodiol dehydrogenase/bile acid-binding protein; DD/BABP; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;1.3.1.20 ; Type III 3-alpha-hydroxysteroid dehydrogenase;1.1.1.357 ; AKR1C2; DDH2

Cancer, Developmental Biology, Drug Metabolism, Endocrine Metabolism, Energy Metabolism, Energy Transfer Pathways, Growth Factors/Hormones, Hormone Biosynthesis, Lipid Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Reproduction, Signal Transduction, Tumor Biomarkers

Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) . Has a high bile-binding ability. .

1. Ciaccio PJ, Tew KD (Jun 1994) . cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase. Biochimica et Biophysica Acta 1186 (1-2) : 129–32. 2. O'connor T, Ireland LS, Harrison DJ, Hayes JD (Oct 1999) . Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. The Biochemical Journal 343 (2) : 487–504.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.