Anti-Adenylate Kinase 1/AK1 Antibody Picoband® Fluoro488 Conjugated
Selected Variant
PB10033-Fluoro488
Size: 100 µg/Vial
Product Specifications
Background
This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Synonyms
Adenylate kinase isoenzyme 1 ; AK 1 ;2.7.4.3 ;2.7.4.6 ; ATP-AMP transphosphorylase 1 ; ATP:AMP phosphotransferase ; Adenylate monophosphate kinase ; Myokinase ; AK1
Gene Name
AK1
Gene ID
203
UniProt
P00568
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Adenylate Kinase 1, different from the related mouse sequence by seven amino acids, and from the related rat sequence by four amino acids.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Highest level in placenta, liver, muscle and kidney.
Applications
Flow Cytometry
Field of Research
Amino Acids, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. .
References & Citations
1. Bianchi, P., Zappa, M., Bredi, E., Vercellati, C., Pelissero, G., Barraco, F., Zanella, A. A case of complete adenylate kinase deficiency due to a nonsense mutation in AK-1 gene (arg107-to-stop, CGA-to-TGA) associated with chronic haemolytic anaemia. Brit. J. Haemat. 105: 75-79, 1999. 2. Qualtieri, A., Pedace, V., Bisconte, M. G., Bria, M., Gulino, B., Andreoli, V., Brancati, C. Severe erythrocyte adenylate kinase deficiency due to homozygous A-to-G substitution at codon 164 of human AK1 gene associated with chronic haemolytic anaemia. Brit. J. Haemat. 99: 770-776, 1997.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
21635 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Adenylate kinase isoenzyme 1
Subcellular Location
Cytoplasm.
Protein Name
Adenylate kinase isoenzyme 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Price
Sign In for Pricing
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040178-500 1x 500 µL
CD50 (ICAM-3) (186-2G9), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680775-500 1x 500 µL
Pgp9.5 (UCHL-1) (UCHL1/775), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC042553-100 1x 100 µL
ATG5 (Autophagy Marker) (ATG5/2553), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC742932-500 1x 500 µL
FCGRT / FcRn (IgG Transporter) (FCGRT/2932), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402275-500 1x 500 µL
P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
A00664-4 100 µg/Vial
Anti-Poliovirus Receptor/PVR Antibody Picoband®
Sign In for Pricing
View Details