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Anti-ADH4 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Alcohol dehydrogenase 4 is an enzyme that in humans is encoded by the ADH4 gene. This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.

Synonyms

Alcohol dehydrogenase 4;1.1.1.1; Alcohol dehydrogenase class II pi chain; ADH4

Gene Name

ADH4

Gene ID

127

UniProt

P08319

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human ADH4 recombinant protein (Position: K218-F380) . Human ADH4 shares 68.7% and 71.8% amino acid (aa) sequence identity with mouse and rat ADH4, respectively.

Clonality

Polyclonal

Tissue Specificity

Plasma. Expressed primarily in liver. .

Applications

Flow Cytometry

Field of Research

Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. .

References & Citations

1. Li M, Edenberg HJ (1998) . Function of cis-acting elements in human alcohol dehydrogenase 4 (ADH4) promoter and role of C/EBP proteins in gene expression.. DNA Cell Biol. 17 (4) : 387–97. 2. Luo X, Kranzler HR, Zuo L, et al. (2006) . ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies..Pharmacogenet. Genomics 15 (11) : 755–68.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

40 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Alcohol dehydrogenase 4

Subcellular Location

Cytoplasm.

Protein Name

Alcohol dehydrogenase 4

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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