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Anti-Alcohol Dehydrogenase/ADH1A Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Alcohol dehydrogenase 1A is an enzyme that in humans is encoded by the ADH1A gene. This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. And this gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence.

Synonyms

Alcohol dehydrogenase 1A;1.1.1.1; Alcohol dehydrogenase subunit alpha; ADH1A; ADH1

Gene Name

ADH1A

Gene ID

124

UniProt

P07327

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived human ADH1A recombinant protein (Position: K213-F375) . Human ADH1A shares 87.1% and 82.8% amino acid (aa) sequence identity with mouse and rat ADH1A, respectively.

Clonality

Polyclonal

Tissue Specificity

Plasma. Expressed primarily in liver. .

Applications

Flow Cytometry

Field of Research

Cancer, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. .

References & Citations

1. Lange LG, Sytkowski AJ, Vallee BL (1976) . Human liver alcohol dehydrogenase: purification, composition, and catalytic features.Biochemistry 15 (21) : 4687–93. 2. Smith M (Mar 1986) . Genetics of human alcohol and aldehyde dehydrogenases. Adv Hum Genet 15: 249–90.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

39859 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Alcohol dehydrogenase 1A

Subcellular Location

Cytoplasm.

Protein Name

Alcohol dehydrogenase 1A

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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