Anti-ADAMTS13 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

ADAMTS13 (a disintegrin and metalloproteinase with athrombospondin type 1 motif, member 13), also known as VWFCP, is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting. It is secreted in blood and degrades large vWf multimers, decreasing their activity. This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. This gene is mapped to 9q34.

Synonyms

A disintegrin and metalloproteinase with thrombospondin motifs 13; ADAM-TS 13; ADAM-TS13; ADAMTS-13;3.4.24.87; von Willebrand factor-cleaving protease; vWF-CP; vWF-cleaving protease; ADAMTS13; C9orf8; UNQ6102/PRO20085

Gene Name

ADAMTS13

Gene ID

11093

UniProt

Q76LX8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived human ADAMTS13 recombinant protein (Position: A299-R488) . Human ADAMTS13 shares 85.2% amino acid (aa) sequence identity with mouse ADAMTS13.

Clonality

Polyclonal

Tissue Specificity

Plasma. Expressed primarily in liver. .

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. .

References & Citations

1. Fujimura Y, Matsumoto M, Yagi H, et al. (2002) . Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome.. Int. J. Hematol. 75 (1) : 25–34. 2. Furlan M, Lämmle B (2001) . Aetiology and pathogenesis of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome: the role of von Willebrand factor-cleaving protease. Best Pract Res Clin Haematol 14 (2) : 437–54.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

153604 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

A disintegrin and metalloproteinase with thrombospondin motifs 13

Subcellular Location

Secreted . Secretion enhanced by O-fucosylation of TSP type-1 repeats.

Protein Name

A disintegrin and metalloproteinase with thrombospondin motifs 13

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-ADAMTS13 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Protein Name

Isotype

Contents

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