What sizes are available for Anti-ABCE1 Antibody Picoband® Fluoro488 Conjugated?

Anti-ABCE1 Antibody Picoband® Fluoro488 Conjugated is available in the following size(s): 100 µg/Vial.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

Anti-ABCE1 Antibody Picoband® Fluoro488 Conjugated

Q: What is the catalog number for Anti-ABCE1 Antibody Picoband® Fluoro488 Conjugated?

The catalog number for Anti-ABCE1 Antibody Picoband® Fluoro488 Conjugated is PB10020-Fluoro488.

Q: Is Anti-ABCE1 Antibody Picoband® Fluoro488 Conjugated in stock?

Anti-ABCE1 Antibody Picoband® Fluoro488 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

Product Specifications

Background

ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumorcell proliferation and antiapoptosis.

Synonyms

ATP-binding cassette sub-family E member 1;2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I; ABCE1; RLI, RNASEL1, RNASELI, RNS4I; OK/SW-cl.40

Gene Name

ABCE1

Gene ID

6059

UniProt

P61221

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human ABCE1 recombinant protein (Position: K419-D599) . Human ABCE1 shares 100% amino acid (aa) sequence identity with mouse ABCE1.

Clonality

Polyclonal

Tissue Specificity

Liver > pancreas > brain > kidney > heart > placenta.

Applications

Flow Cytometry

Field of Research

Adapters, Antiviral Signaling, ATPases, Chaperones, Immune System Diseases, Immunology, Metabolism, Plasma Membrane, Protein Trafficking, Signal Transduction, Transmembrane

Purification

Immunogen affinity purified.

Form

Liquid

Function

Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. .

References & Citations

1. Tian, Y; Han, X; Tian, DL (2012) . The biological regulation of ABCE1. IUBMB Life 64 (10) : 795–800.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

67314 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

ATP-binding cassette sub-family E member 1

Subcellular Location

Cytoplasm . Mitochondrion . Localized to clusters of virus formation at the plasma membrane.

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.

Protein Name

ATP-binding cassette sub-family E member 1

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Frequently Asked Questions

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Anti-ABCE1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Sequence Similarities

Protein Name

Isotype

Contents

Frequently Asked Questions

Explore Other Products

MART-1 / Melan-A (M2-7C10), CF740 conjugate, 0.1mg/mL

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Human IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) (rIM373), CF488A conjugate, 0.1mg/mL

Fibronectin (TV-1), CF568 conjugate, 0.1mg/mL

Prolactin (Pituitary Tumor Marker) (PRL/2910), CF594 conjugate, 0.1mg/mL

Calnexin (Endoplasmic Reticulum Marker) (CANX/1541), CF594 conjugate, 0.1mg/mL