Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-ABCE1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

ATP binding cassette E1 (ABCE1, also RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumorcell proliferation and antiapoptosis.

Synonyms

ATP-binding cassette sub-family E member 1;2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I; ABCE1; RLI, RNASEL1, RNASELI, RNS4I; OK/SW-cl.40

Gene Name

ABCE1

Gene ID

6059

UniProt

P61221

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human ABCE1 recombinant protein (Position: K419-D599) . Human ABCE1 shares 100% amino acid (aa) sequence identity with mouse ABCE1.

Clonality

Polyclonal

Tissue Specificity

Liver > pancreas > brain > kidney > heart > placenta.

Applications

Flow Cytometry

Field of Research

Adapters, Antiviral Signaling, ATPases, Chaperones, Immune System Diseases, Immunology, Metabolism, Plasma Membrane, Protein Trafficking, Signal Transduction, Transmembrane

Purification

Immunogen affinity purified.

Form

Liquid

Function

Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. .

References & Citations

1. Tian, Y; Han, X; Tian, DL (2012) . The biological regulation of ABCE1. IUBMB Life 64 (10) : 795–800.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

67314 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

ATP-binding cassette sub-family E member 1

Subcellular Location

Cytoplasm . Mitochondrion . Localized to clusters of virus formation at the plasma membrane.

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.

Protein Name

ATP-binding cassette sub-family E member 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)
MBS1057855-01 0.02 mg (E-Coli)

Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)

Ask
View Details
Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)
MBS1057855-02 0.02 mg (Yeast)

Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)

Ask
View Details
Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)
MBS1057855-03 0.1 mg (E-Coli)

Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)

Ask
View Details
Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)
MBS1057855-04 0.1 mg (Yeast)

Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)

Ask
View Details
Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)
MBS1057855-05 0.02 mg (Baculovirus)

Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)

Ask
View Details
Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)
MBS1057855-06 0.02 mg (Mammalian-Cell)

Recombinant Thermosynechococcus elongatus Acetylornithine aminotransferase (argD)

Ask
View Details