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Anti-ZWINT Antibody Picoband® Fluoro647 Conjugated

Selected Variant

PB10018-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene. This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms

ZW10 interactor; ZW10-interacting protein 1; Zwint-1; ZWINT

Gene Name

ZWINT

Gene ID

11130

UniProt

O95229

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human ZWINT recombinant protein (Position: Q29-Q249) . Human ZWINT shares 58% and 57.1% amino acid (aa) sequence identity with mouse and rat ZWINT, respectively.

Clonality

Polyclonal

Tissue Specificity

Detected in all tissues tested.

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Division, Chromosome Structure, Epigenetics and Nuclear Signaling, Spindle

Purification

Immunogen affinity purified.

Form

Liquid

Function

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. .

References & Citations

1. Entrez Gene: ZWINT ZW10 interactor. 2. Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004) . A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nature Cell Biology 6 (11) : 1135–41. 3. van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008) . A unique residue in rab3c determines the interaction with novel binding protein Zwint-1. FEBS Letters 582 (19) : 2838–42.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

31293 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

ZW10 interactor

Subcellular Location

Nucleus. Chromosome, centromere, kinetochore. Localizes to kinetochores from late prophase to anaphase.

Sequence Similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.

Protein Name

ZW10 interactor

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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