Anti-Carboxypeptidase B2/CPB2 Antibody Picoband® Fluoro550 Conjugated

Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

E. coli-derived human CPB2 recombinant protein (Position: K166-D388) . Human CPB2 shares 86.1% and 85.7% amino acid (aa) sequence identity with mouse and rat CPB2, respectively.

Amino Acid Metabolism, Amino Acids, Atherosclerosis, Cardiovascular, Heart Disease, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Serum Proteins, Signal Transduction

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. .

1. Boffa MB, Reid TS, Joo E, Nesheim ME, Koschinsky ML (May 1999) . Characterization of the gene encoding human TAFI (thrombin-activable fibrinolysis inhibitor; plasma procarboxypeptidase B) . Biochemistry 38 (20) : 6547–58. 2. Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D (Dec 1991) . Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma. J Biol Chem 266 (32) : 21833–8. 3. Tsai SP, Drayna D (Dec 1992) . The gene encoding human plasma carboxypeptidase B (CPB2) resides on chromosome 13. Genomics14 (2) : 549–50.