Anti-TCP1 beta/CCT2 Antibody Picoband® Fluoro647 Conjugated

T-complex protein 1 subunit beta (TCP1 beta) is a protein that in humans is encoded by the CCT2 gene. The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC) . This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene.

E.coli-derived human CCT2 recombinant protein (Position: E414-C535) . Human CCT2 shares 95.9% and 93.4% amino acid (aa) sequence identity with mouse and rat CCT2, respectively.

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. .

1. Entrez Gene: CCT2 chaperonin containing TCP1, subunit 2 (beta) . 2. Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998) . Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. Molecular and Cellular Biology 18 (12) : 7584–9.