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Anti-Bcr Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

The breakpoint cluster region protein (BCR) is a protein that in humans is encoded by the BCR gene. A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

Breakpoint cluster region protein;2.7.11.1; Renal carcinoma antigen NY-REN-26; BCR; BCR1, D22S11

Gene Name

BCR

Gene ID

613

UniProt

P11274

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Bcr recombinant protein (Position: M1-A100) . Human Bcr shares 94% amino acid (aa) sequence identity with mouse Bcr.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous, with higher levels in heart, substantia nigra, and kidney. .

Applications

Flow Cytometry

Field of Research

Cancer, G Protein Signaling, Protein Phosphorylation, Ras Family, Ser/Thr Kinases, Serine/Threonine Kinases, Signal Transduction, Signaling Pathway, Small G Proteins

Purification

Immunogen affinity purified.

Form

Liquid

Function

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. .

References & Citations

1. Entrez Gene: Breakpoint cluster region. 2. Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T (February 1994) . Bcr-Abl oncoproteins bind ly to activators of the Ras signalling pathway. EMBO J. 13 (4) : 764–73. 3. Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON (July 1991) . BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner.Cell 66 (1) : 161–71.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

142819 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Breakpoint cluster region protein

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density .

Protein Name

Breakpoint cluster region protein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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