Anti-AMHR2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
AMHR2 is the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms
Anti-Muellerian hormone type-2 receptor;2.7.11.30; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII; AMHR2; AMHR, MISR2
Gene Name
AMHR2
Gene ID
269
UniProt
Q16671
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human AMHR2, different from the related mouse and rat sequences by three amino acids.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.
Applications
Flow Cytometry
Field of Research
Growth Factors/Hormones, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Signaling Pathways, Stem Cells, Surface Molecules, TGF Beta
Purification
Immunogen affinity purified.
Form
Liquid
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
References & Citations
1. Behringer RR (1994) . The in vivo roles of müllerian-inhibiting substance. Current Topics in Developmental Biology. Current Topics in Developmental Biology 29: 171–87. 2. Cate RL, Mattaliano RJ, Hession C, Tizard R, Farber NM, Cheung A, Ninfa EG, Frey AZ, Gash DJ, Chow EP (Jun 1986) . Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells. Cell 45 (5) : 685–98.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
62750 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Anti-Muellerian hormone type-2 receptor
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
Anti-Muellerian hormone type-2 receptor
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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