Anti-ALDH3A2 Antibody Picoband® Fluoro488 Conjugated

Fatty aldehyde dehydrogenase (or Long-chain-aldehyde dehydrogenase) is an aldehyde dehydrogenase enzyme that in human is encoded in the ALDH3A2 gene on chromosome 17. ALDH3A2 catalyzes the oxidation of long-chain aliphatic aldehydes into fatty acids. It is known to act on a variety of both saturated and unsaturated aliphatic aldehydes between 6 to 24 carbons in length, as well as dihydrophytal, a 20-carbon branched chain aldehyde. It requires NAD+ as a co-factor. The encoded enzyme is responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. ALD3H2 is expressed in the human liver and has been found to localize the microsome fraction inside the cell.

Fatty aldehyde dehydrogenase;1.2.1.3; Aldehyde dehydrogenase 10; Aldehyde dehydrogenase family 3 member A2; Microsomal aldehyde dehydrogenase; ALDH3A2; ALDH10, FALDH

E.coli-derived human ALDH3A2 recombinant protein (Position: M1-Q100) . Human ALDH3A2 shares 78% amino acid (aa) sequence identity with both mouse and rat ALDH3A2.

Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.

Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. .

1. Kelson TL, Secor McVoy JR, Rizzo WB (1997) . Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization. Biochim. Biophys. Acta 1335 (1-2) : 99–110. 2. Rogers GR, Markova NG, De Laurenzi V, Rizzo WB, Compton JG (1997) . Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH) . Genomics 39 (2) : 127–35.