Anti-Argonaute 4/AGO4 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
AGO4 (Argonaute 4) is also known as EIF2C4. This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1.
Synonyms
Protein argonaute-4 ; Argonaute4 ; hAgo4; Argonaute RISC catalytic component 4; Eukaryotic translation initiation factor 2C 4 ; eIF-2C 4 ; eIF2C 4 ; AGO4; EIF2C4, KIAA1567
Gene Name
AGO4
Gene ID
192670
UniProt
Q9HCK5
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Argonaute 4, identical to the related mouse sequence.
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed, highest levels were found in brain and lung. Isoform 5 is expressed at higher levels in astrocytomas as compared to normal brain tissue and expression increases strikingly with the severity of the tumor, being higher in the most aggressive tumors. .
Applications
Flow Cytometry
Field of Research
DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing
Purification
Immunogen affinity purified.
Form
Liquid
Function
Required for RNA-mediated gene silencing (RNAi) . Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-ed transcription and replication of the human hapatitis delta virus (HDV) . .
References & Citations
1. Carmell, M. A., Xuan, Z., Zhang, M. Q., Hannon, G. J. The argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 16: 2733-2742, 2002. 2. Nagase, T., Kikuno, R., Nakayama, M., Hirosawa, M., Ohara, O. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7: 273-281, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
97097 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Protein argonaute-4
Subcellular Location
Cytoplasm, P-body .
Protein Name
Protein argonaute-4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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