Anti-AEBP2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Adipocyte Enhancer-Binding Protein is a zinc finger protein that in humans is encoded by the evolutionarily well-conserved gene AEBP2. This gene is mapped to 12p12.3. AEBP2 is a DNA-binding transcriptional repressor. It may regulate the migration and development of the neural crest cells through the PRC2-mediated epigenetic mechanism and is most likely a targeting protein for the mammalian PRC2 complex.
Synonyms
Zinc finger protein AEBP2; Adipocyte enhancer-binding protein 2; AE-binding protein 2; AEBP2
Gene Name
AEBP2
Gene ID
121536
UniProt
Q6ZN18
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human AEBP2 recombinant protein (Position: K424-Q517) . Human AEBP2 shares 98.8% amino acid (aa) sequence identity with mouse AEBP2.
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed, highest levels were found in brain and lung. Isoform 5 is expressed at higher levels in astrocytomas as compared to normal brain tissue and expression increases strikingly with the severity of the tumor, being higher in the most aggressive tumors. .
Applications
Flow Cytometry
Field of Research
Chromatin Binding Proteins, Chromatin Remodeling, DNA/RNA Binding, Domain Families, Epigenetics and Nuclear Signaling, Transcription, Transcription Factors, Zinc Finger
Purification
Immunogen affinity purified.
Form
Liquid
Function
DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. .
References & Citations
1. Imhof, Axel; Kim, Hana; Bakshi, Arundhati; Kim, Joomyeong (2015) . Retrotransposon-Derived Promoter of Mammalian Aebp2. PLOS ONE 10 (4) : e0126966. 2. Kim H, Kang K, Kim J (2009) . AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. Nucleic Acids Res. 37 (9) : 2940–50.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
54467MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Zinc finger protein AEBP2
Subcellular Location
Nucleus .
Protein Name
Zinc finger protein AEBP2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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