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Anti-AEBP2 Antibody Picoband®

Boster Bio Anti-AEBP2 Antibody Picoband® catalog # PB9977. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Adipocyte Enhancer-Binding Protein is a zinc finger protein that in humans is encoded by the evolutionarily well-conserved gene AEBP2. This gene is mapped to 12p12.3. AEBP2 is a DNA-binding transcriptional repressor. It may regulate the migration and development of the neural crest cells through the PRC2-mediated epigenetic mechanism and is most likely a targeting protein for the mammalian PRC2 complex.

Synonyms

Zinc finger protein AEBP2; Adipocyte enhancer-binding protein 2; AE-binding protein 2; AEBP2

Gene Name

AEBP2

Gene ID

121536

UniProt

Q6ZN18

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human AEBP2 recombinant protein (Position: K424-Q517) . Human AEBP2 shares 98.8% amino acid (aa) sequence identity with mouse AEBP2.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed, highest levels were found in brain and lung. Isoform 5 is expressed at higher levels in astrocytomas as compared to normal brain tissue and expression increases strikingly with the severity of the tumor, being higher in the most aggressive tumors. .

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Chromatin Binding Proteins, Chromatin Remodeling, DNA/RNA Binding, Domain Families, Epigenetics and Nuclear Signaling, Transcription, Transcription Factors, Zinc Finger

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. .

References & Citations

1. Imhof, Axel; Kim, Hana; Bakshi, Arundhati; Kim, Joomyeong (2015) . Retrotransposon-Derived Promoter of Mammalian Aebp2. PLOS ONE 10 (4) : e0126966. 2. Kim H, Kang K, Kim J (2009) . AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. Nucleic Acids Res. 37 (9) : 2940–50.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

54467MW

Observed Molecular Weight

54 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Zinc finger protein AEBP2

Subcellular Location

Nucleus .

Protein Name

Zinc finger protein AEBP2

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

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