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Anti-Aconitase 2/ACO2 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

PB9973-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Aconitase 2, mitochondrial is a protein that in humans is encoded by the ACO2 gene. The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15 (PRSS15), also known as Lon protease, after oxidative modification.

Synonyms

Aconitate hydratase, mitochondrial; Aconitase;4.2.1.3; Citrate hydro-lyase; ACO2

Gene Name

ACO2

Gene ID

50

UniProt

Q99798

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Aconitase 2, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Highly enriched in the brain. Much weaker expression in heart, lung and muscle.

Applications

Flow Cytometry

Field of Research

Cancer, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Mitochondria, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Organelles, Pathways and Processes, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. .

References & Citations

1. Entrez Gene: Aconitase 2, mitochondrial. 2. Geurts van Kessel, A. H. M., Westerveld, A., de Groot, P. G., Meera Khan, P., Hagemeijer, A. Regional localization of the genes coding for human ACO2, ARSA, and NAGA on chromosome 22. Cytogenet. Cell Genet. 28: 169-172, 1980. 3. Mirel, D. B., Marder, K., Graziano, J., Freyer, G., Zhao, Q., Mayeux, R., Wilhelmsen, K. C. Characterization of the human mitochondrial aconitase gene (ACO2) . Gene 213: 205-218, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

85425 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Aconitate hydratase, mitochondrial

Subcellular Location

Mitochondrion .

Protein Name

Aconitate hydratase, mitochondrial

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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