Anti-SR1/SRI Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Sorcin is a protein that in humans is encoded by the SRI gene. It is mapped to 7q21.1. This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene.
Synonyms
Sorcin;22 kDa protein; CP-22; CP22; V19; SRI
Gene Name
SRI
Gene ID
6717
UniProt
P30626
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human SR1, different from the related mouse sequence by one amino acid.
Clonality
Polyclonal
Tissue Specificity
Detected in cardiac myocytes.
Applications
Flow Cytometry
Field of Research
Neuropeptides, Neuroscience, Neurotransmitter
Purification
Immunogen affinity purified.
Form
Liquid
Function
Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. .
References & Citations
1. Entrez Gene: SRI sorcin. 2. Meyers, M B; Pickel V M; Sheu S S; Sharma V K; Scotto K W; Fishman G I (Nov 1995) . Association of sorcin with the cardiac ryanodine receptor. J. Biol. Chem. (UNITED STATES) 270 (44) : 26411–8. 3. Van der Bliek AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF, Hamilton TC, Joenje H, Borst P (Nov 1988) . Genes amplified and overexpressed in human multidrug-resistant cell lines. Cancer Res48 (21) : 5927–32.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
21676 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Sorcin
Subcellular Location
Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.
Protein Name
Sorcin
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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