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Anti-SR1/SRI Antibody Picoband®

Selected Variant

RP1110

Size: 100 µg/Vial

Boster Bio Anti-SR1/SRI Antibody catalog # RP1110. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Sorcin is a protein that in humans is encoded by the SRI gene. It is mapped to 7q21.1. This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene.

Synonyms

Sorcin;22 kDa protein; CP-22; CP22; V19; SRI

Gene Name

SRI

Gene ID

6717

UniProt

P30626

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human SR1, different from the related mouse sequence by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Detected in cardiac myocytes.

Applications

WB

Field of Research

Neuropeptides, Neuroscience, Neurotransmitter

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. .

References & Citations

1. Entrez Gene: SRI sorcin. 2. Meyers, M B; Pickel V M; Sheu S S; Sharma V K; Scotto K W; Fishman G I (Nov 1995) . Association of sorcin with the cardiac ryanodine receptor. J. Biol. Chem. (UNITED STATES) 270 (44) : 26411–8. 3. Van der Bliek AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF, Hamilton TC, Joenje H, Borst P (Nov 1988) . Genes amplified and overexpressed in human multidrug-resistant cell lines. Cancer Res48 (21) : 5927–32.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

21676 MW

Observed Molecular Weight

26 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Sorcin

Subcellular Location

Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.

Protein Name

Sorcin

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Price

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