Anti-ZP1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Zona pellucida sperm-binding protein 1 (ZP1) is a protein that belopngs to the mammalian zona pellucida. The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. Zp1 ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. And this gene is mapped to chromosome 11q12.2.
Synonyms
Zona pellucida sperm-binding protein 1; Zona pellucida glycoprotein 1; Zp-1; Processed zona pellucida sperm-binding protein 1; ZP1
Gene Name
ZP1
Gene ID
22917
UniProt
P60852
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human ZP1, different from the related mouse sequence by four amino acids, and from the related rat sequence by five amino acids.
Clonality
Polyclonal
Tissue Specificity
Oocytes.
Applications
Flow Cytometry
Field of Research
Developmental Biology, Germ Cell Markers, Reproduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.
References & Citations
1. Gross, M. B. Personal Communication. Baltimore, Md. 6/24/2014. 2. Huang, Hua-Lin; Lv, Chao; Zhao, Ying-Chun; Li, Wen; He, Xue-Mei; Li, Ping; Sha, Ai-Guo; Tian, Xiao; Papasian, Christopher J.; Deng, Hong-Wen; Lu, Guang-Xiu; Xiao, Hong-Mei (2014) . Mutant ZP1 in Familial Infertility. New England Journal of Medicine 370 (13) : 1220–1226. 3. Rankin, T., Talbot, P., Lee, E., Dean, J. Abnormal zonae pellucidae in mice lacking ZP1 result in early embryonic loss.Development 126: 3847-3855, 1999.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
70049 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Zona pellucida sperm-binding protein 1
Subcellular Location
Processed zona pellucida sperm-binding protein 1: Secreted, extracellular space, extracellular matrix . The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida. .
Protein Name
Zona pellucida sperm-binding protein 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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