Anti-WDR1 Antibody Picoband® Fluoro488 Conjugated

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene. It is mapped to 4p16.1. This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458) . Enhances cofilin-mediated actin severing (By similarity) . Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608) . Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity) . Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity) . Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565) . .

1. Entrez Gene: WDR1 WD repeat domain 1. 2. Adler HJ, Winnicki RS, Gong TW, Lomax MI (May 1999) . A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein. Genomics 56 (1) : 59–69. 3. Fujibuchi T, Abe Y, Takeuchi T, et al. (2005) . AIP1/WDR1 supports mitotic cell rounding. Biochem. Biophys. Res. Commun. 327 (1) : 268–75.