Anti-Talin 2/TLN2 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Talin 2 is a protein in humans that is encoded by the TLN2 gene. It belongs to the talin protein family. This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. Talin-2 is expressed at high levels in cardiac muscle and functions to provide linkages between the extracellular matrix and actin cytoskeleton at costamere structures to transduce force laterally.
Synonyms
Talin-2; TLN2; KIAA0320
Gene Name
TLN2
Gene ID
83660
UniProt
Q9Y4G6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human Talin 2.
Clonality
Polyclonal
Tissue Specificity
Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.
Applications
Flow Cytometry
Field of Research
Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity) . .
References & Citations
1. Entrez Gene: Talin 2. 2. Monkley SJ, Pritchard CA, Critchley DR (Sep 2001) . Analysis of the mammalian talin2 gene TLN2. Biochemical and Biophysical Research Communications 286 (5) : 880–5. 3. Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ (Mar 2012) . New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2. European Journal of Cell Biology 91 (3) : 180–91.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
271613 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Talin-2
Subcellular Location
Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Focal adhesion plaques and synapses.
Protein Name
Talin-2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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