Anti-Alpha 1 Acid Glycoprotein/ORM1 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene. The structural gene for orosomucoid (ORM1) is assigned to the end of the long arm of chromosome 9 by demonstration of linkage to ABO and AK1. This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.
Synonyms
Alpha-1-acid glycoprotein 1; AGP 1; Orosomucoid-1; OMD 1; ORM1; AGP1
Gene Name
ORM1
Gene ID
5004
UniProt
P02763
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E. coli-derived human ORM1 recombinant protein (Position: Q19-S201) . Human ORM1 shares 47.5% and 48.1% amino acid (aa) sequence identity with mouse and rat ORM1, respectively.
Clonality
Polyclonal
Tissue Specificity
Expressed by the liver and secreted in plasma.
Applications
Flow Cytometry
Field of Research
Cardiovascular, Immunology, Innate Immunity, Macrophage/Inflammation, Secreted Molecules, Serum Proteins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. .
References & Citations
1. Entrez Gene: ORM1 orosomucoid 1. 2. Boncela, J; Papiewska I; Fijalkowska I; Walkowiak B; Cierniewski C S (Sep 2001) . Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity. J. Biol. Chem. (United States) 276 (38) : 35305–11. 3. Eiberg, H., Mohr, J., Nielsen, L. S. Linkage of orosomucoid (ORM) to ABO and AK1. (Abstract) Cytogenet. Cell Genet. 32: 272 only, 1982.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
23512 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Alpha-1-acid glycoprotein 1
Subcellular Location
Secreted.
Protein Name
Alpha-1-acid glycoprotein 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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