Anti-MGP Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Matrix Gla protein (MGP) is an 84-residue vitamin K-dependent protein initially isolated from bovine bone. In addition, MGP is a 10-kD protein produced and secreted by vascular smooth muscle cells and chondrocytes and significantly accumulated in bone, cartilage, and dentin. It is also expressed at high levels in heart, kidney, and lung and is upregulated by vitamin D in bone cells. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization. And this gene is mapped to 12p12.3.
Synonyms
Matrix Gla protein; MGP; Cell growth-inhibiting gene 36 protein; MGP; MGLAP; GIG36
Gene Name
MGP
Gene ID
4256
UniProt
P08493
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human MGP recombinant protein (Position: Y20-F96) . Human MGP shares 84.4% and 80.5% amino acid (aa) sequence identity with mouse and rat MGP, respectively.
Clonality
Polyclonal
Tissue Specificity
Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined. .
Applications
Flow Cytometry
Field of Research
Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction, Structures
Purification
Immunogen affinity purified.
Form
Liquid
Function
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
References & Citations
1. Hur, D. J., Raymond, G. V., Kahler, S. G., Riegert-Johnson, D. L., Cohen, B. A., Boyadjiev, S. A. A novel MGP mutation in a consanguineous family: review of the clinical and molecular characteristics of Keutel syndrome. Am. J. Med. Genet. 135A: 36-40, 2005. 2. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G (March 1997) . Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386 (6620) : 78–81. 3. Yao Y, Jumabay M, Ly A, Radparvar M, Cubberly MR, Boström KI (2013) . A role for the endothelium in vascular calcification. Circ. Res. 113 (5) : 495–504.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
12353 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Matrix Gla protein
Subcellular Location
Secreted.
Protein Name
Matrix Gla protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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