Anti-GAL4/LGALS4 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Galectin-4 is a protein that in humans is encoded by the LGALS4 gene. This gene is mapped to chromosome 19q13.2 based on an alignment of the LGALS4 sequence. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS4 is an S-type lectin that is strongly underexpressed in colorectal cancer. The 323-amino acid LGALS4 protein contains 2 homologous, approximately 150-amino acid carbohydrate recognition domains and all amino acids typically conserved in galectins.
Synonyms
Galectin-4; Gal-4; Antigen NY-CO-27; L-36 lactose-binding protein; L36LBP; Lactose-binding lectin 4; LGALS4
Gene Name
LGALS4
Gene ID
3960
UniProt
P56470
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human GAL4, different from the related mouse and rat sequences by seven amino acids.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cancer, Cell Adhesion,2339, Cytoskeleton/ECM, Energy Metabolism, Energy Transfer Pathways, Epigenetics and Nuclear Signaling, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Tags & Cell Markers, Transcription, Transcription Factors
Purification
Immunogen affinity purified.
Form
Liquid
Function
Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
References & Citations
1. Entrez Gene: LGALS4 lectin, galactoside-binding, soluble, 4 (galectin 4) . 2. Barondes SH, Cooper DN, Gitt MA, Leffler H (Sep 1994) . Galectins. Structure and function of a large family of animal lectins. J Biol Chem 269 (33) : 20807–10. 3. Rechreche, H., Mallo, G. V., Montalto, G., Dagorn, J.-C., Iovanna, J. L. Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer. Europ. J. Biochem. 248: 225-230, 1997.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
35941 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Galectin-4
Subcellular Location
Cytoplasm. Secreted . Exists in three distinct states: free within the cell, released into the extracellular space, or conjugated to target proteins. .
Protein Name
Galectin-4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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