What sizes are available for Anti-Collagen I/COL1A1 Antibody Picoband® Fluoro594 Conjugated?

Anti-Collagen I/COL1A1 Antibody Picoband® Fluoro594 Conjugated is available in the following size(s): 100 µg/Vial.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

Anti-Collagen I/COL1A1 Antibody Picoband® Fluoro594 Conjugated

Q: What is the catalog number for Anti-Collagen I/COL1A1 Antibody Picoband® Fluoro594 Conjugated?

The catalog number for Anti-Collagen I/COL1A1 Antibody Picoband® Fluoro594 Conjugated is PB9938-Fluoro594.

Product Specifications

Background

Collagen, type I, alpha 1, also known as COL1A1, is a human gene that encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. This gene is mapped to 17q21.33. And this gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis.

Synonyms

Collagen alpha-1 (I) chain; Alpha-1 type I collagen; COL1A1

Gene Name

COL1A1

Gene ID

1277

UniProt

P02452

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen I, different from the related mouse and rat sequences by four amino acids.

Clonality

Polyclonal

Tissue Specificity

Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Applications

Flow Cytometry

Field of Research

Collagen, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Mesenchymal Stem Cells, Signal Transduction, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Type I collagen is a member of group I collagen (fibrillar forming collagen) .

References & Citations

1. Aihara, M., Lindsey, J. D., Weinreb, R. N. Ocular hypertension in mice with a targeted type I collagen mutation. Invest. Ophthal. Vis. Sci. 44: 1581-1585, 2003. 2. Cabral, W. A., Makareeva, E., Colige, A., Letocha, A. D., Ty, J. M., Yeowell, H. N., Pals, G., Leikin, S., Marini, J. C. Mutations near amino end of alpha-1 (I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. J. Biol. Chem. 280: 19259-19269, 2005.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

138941 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Collagen alpha-1 (I) chain

Subcellular Location

Secreted, extracellular space, extracellular matrix .

Protein Name

Collagen alpha-1 (I) chain

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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