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Anti-CD27 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

CD27 is a member of the tumor necrosis factor receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. And this receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

Synonyms

CD27 antigen; CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD27; CD27; TNFRSF7

Gene Name

CD27

Gene ID

939

UniProt

P26842

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived human CD27 recombinant protein (Position: A20-R191) . Human CD27 shares 62.8% amino acid (aa) sequence identity with mouse CD27.

Clonality

Polyclonal

Tissue Specificity

Found in most T-lymphocytes.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Cancer, Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Lymphoid, Stem Cells, T Cells, T Lymphocytic Lineage, TNF Superfamily, Tumor Immunology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

References & Citations

1. Entrez Gene: CD27 CD27 molecule. 2. Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (Jun 1997) . CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proceedings of the National Academy of Sciences of the United States of America 94 (12) : 6346–51. 3. Yamamoto H, Kishimoto T, Minamoto S (Nov 1998) . NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27. Journal of Immunology 161 (9) : 4753–9.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

29137 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

CD27 antigen

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

CD27 antigen

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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