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Anti-TCP1 delta/CCT4 Antibody Picoband®

Selected Variant

PB9927

Size: 100 µg/Vial

Boster Bio Anti-TCP1 delta/CCT4 Antibody Picoband® catalog # PB9927. Tested in Flow Cytometry, IP, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

T-complex protein 1 subunit delta is a protein that in humans is encoded by the CCT4 gene. This gene is mapped to 2p15. The chaperonin containing TCP1 complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin and tubulin, as well as alpha-transducin.

Synonyms

T-complex protein 1 subunit delta; TCP-1-delta; CCT-delta; Stimulator of TAR RNA-binding; CCT4; CCTD, SRB

Gene Name

CCT4

Gene ID

10575

UniProt

P50991

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E. coli-derived human CCT4 recombinant protein (Position: R452-R539) . Human CCT4 shares 97.7% amino acid (aa) sequence identity with both mouse and rat CCT4.

Clonality

Polyclonal

Tissue Specificity

Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta. .

Applications

Flow Cytometry, IP, IF, IHC, IHC-F, ICC, WB

Field of Research

Chaperones, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. .

References & Citations

1. Lee, M.-J., Stephenson, D. A., Groves, M. J., Sweeney, M. G., Davis, M. B., An, S.-F., Houlden, H., Salih, M. A. M., Timmerman, V., de Jonghe, P., Auer-Grumbach, M., Di Maria, E., Scaravilli, F., Wood, N. W., Reilly, M. M. Hereditary sensory neuropathy is caused by a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct4) gene. Hum. Molec. Genet. 12: 1917-1925, 2003. 2. Won, K.-A., Schumacher, R. J., Farr, G. W., Horwich, A. L., Reed, S. I. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. Molec. Cell. Biol. 18: 7584-7589, 1998.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

57924 MW

Observed Molecular Weight

58 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

T-complex protein 1 subunit delta

Subcellular Location

Cytoplasm . Melanosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .

Protein Name

T-complex protein 1 subunit delta

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

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