Anti-CAP1 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Adenylyl cyclase-associated protein 1 is an enzyme that in humans is encoded by the CAP1 gene. This gene is mapped to 1p34.2. The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. And the human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants have been identified.
Synonyms
Adenylyl cyclase-associated protein 1; CAP 1; CAP1; CAP
Gene Name
CAP1
Gene ID
10487
UniProt
Q01518
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E. coli-derived human CAP1 recombinant protein (Position: A2-R123) . Human CAP1 shares 92.6% and 93.4% amino acid (aa) sequence identity with mouse and rat CAP1, respectively.
Clonality
Polyclonal
Tissue Specificity
High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular- weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
Applications
Flow Cytometry
Field of Research
Cytoskeleton/ECM, DNA/RNA, Epigenetics and Nuclear Signaling, Extracellular Matrix, RNA Processing, Signal Transduction, Structures
Purification
Immunogen affinity purified.
Form
Liquid
Function
Ly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
References & Citations
1. Entrez Gene: CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) . 2. Hubberstey A, Yu G, Loewith R, Lakusta C, Young D (Apr 1997) . Mammalian CAP interacts with CAP, CAP2, and actin. J Cell Biochem 61 (3) : 459–66. 3. Matviw H, Yu G, Young D (Nov 1992) . Identification of a human cDNA encoding a protein that is structurally and functionally related to the yeast adenylyl cyclase-associated CAP proteins. Mol Cell Biol 12 (11) : 5033–40.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
51901 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Adenylyl cyclase-associated protein 1
Subcellular Location
Cell membrane ; Peripheral membrane protein .
Protein Name
Adenylyl cyclase-associated protein 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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