Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-VRK1 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene. This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. It is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Synonyms

Serine/threonine-protein kinase VRK1;2.7.11.1; Vaccinia-related kinase 1; VRK1

Gene Name

VRK1

Gene ID

7443

UniProt

Q99986

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human VRK1, different from the related mouse sequence by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Highly expressed in fetal liver, testis and thymus. .

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Epigenetics and Nuclear Signaling, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. .

References & Citations

1. Entrez Gene: VRK1 vaccinia related kinase 1. 2. Nezu J, Oku A, Jones MH, Shimane M (Feb 1998) . Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase. Genomics 45 (2) : 327–31.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

45476 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Serine/threonine-protein kinase VRK1

Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle . Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.

Protein Name

Serine/threonine-protein kinase VRK1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Lentiviral mouse Iqcj shRNA (UAS) - Lentiviral mouse Iqcj shRNA (UAS, iRFP) (100)
GTR15278751 1 Vial

Lentiviral mouse Iqcj shRNA (UAS) - Lentiviral mouse Iqcj shRNA (UAS, iRFP) (100)

Ask
View Details
GSK3B Rabbit Monoclonal Antibody [Clone ID: 23GB1175]
TA425086S 20 µL

GSK3B Rabbit Monoclonal Antibody [Clone ID: 23GB1175]

Ask
View Details
HOXA2 Antibody
GWB-MM897F 50 µg

HOXA2 Antibody

Ask
View Details
Recombinant Human ADP-ribosyl Cyclase/cyclic ADP-ribose Hydrolase 1/CD38 (C-Fc)
32-9623-500 500 µg

Recombinant Human ADP-ribosyl Cyclase/cyclic ADP-ribose Hydrolase 1/CD38 (C-Fc)

Ask
View Details