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Anti-NIRF/UHRF2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene. This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.

Synonyms

E3 ubiquitin-protein ligase UHRF2;6.3.2.-; Np95/ICBP90-like RING finger protein; Np95-like RING finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING finger protein 107; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-containing PHD and RING finger domains protein 2; UHRF2; NIRF, RNF107

Gene Name

UHRF2

Gene ID

115426

UniProt

Q96PU4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human NIRF, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. .

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ring Finger E3 Ligase, Ubiquitin E3 Enzymes

Purification

Immunogen affinity purified.

Form

Liquid

Function

E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131. .

References & Citations

1. Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2. 2. Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002) . NIRF, a novel RING finger protein, is involved in cell-cycle regulation. Biochem Biophys Res Commun 296 (3) : 530–6.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

89985 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

E3 ubiquitin-protein ligase UHRF2

Subcellular Location

Nucleus . Enriched at pericentric heterochromatin (PH) . This localization is dependent on the interaction with H3K9me3 (By similarity) . .

Protein Name

E3 ubiquitin-protein ligase UHRF2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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