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Anti-TPP1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Tripeptidyl-peptidase 1, also known as Lysosomal pepstatin-insensitive protease, is an enzyme that in humans is encoded by the TPP1 gene. This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Synonyms

Tripeptidyl-peptidase 1; TPP-1;3.4.14.9; Cell growth-inhibiting gene 1 protein; Lysosomal pepstatin-insensitive protease; LPIC; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase I; TPP-I; TPP1; CLN2; GIG1, UNQ267/PRO304

Gene Name

TPP1

Gene ID

1200

UniProt

O14773

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human TPP1, different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.

Clonality

Polyclonal

Tissue Specificity

Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.

Applications

Flow Cytometry

Field of Research

Cell Biology, Neurodegenerative Disease, Neurogenesis, Neurology Process, Neuroscience, Proteolysis/Ubiquitin, Proteolytic Enzymes

Purification

Immunogen affinity purified.

Form

Liquid

Function

Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity) . .

References & Citations

1. Entrez Gene: TPP1 tripeptidyl peptidase I. 2. Liu CG, Sleat DE, Donnelly RJ, Lobel P (Jun 1998) . Structural organization and sequence of CLN2, the defective gene in classical late infantile neuronal ceroid lipofuscinosis. Genomics 50 (2) : 206–12.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

61248 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Tripeptidyl-peptidase 1

Subcellular Location

Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Protein Name

Tripeptidyl-peptidase 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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