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Anti-STIP1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

STIP1 is an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones. The International Radiation Hybrid Mapping Consortium mapped the STIP1 gene to 11q13.

Synonyms

Stress-induced-phosphoprotein 1; STI1; Hsc70/Hsp90-organizing protein; Hop; Renal carcinoma antigen NY-REN-11; Transformation-sensitive protein IEF SSP 3521; STIP1

Gene Name

STIP1

Gene ID

10963

UniProt

P31948

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human STIP1, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.

Applications

Flow Cytometry

Field of Research

Chaperones, Heat Shock Proteins, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB) .

References & Citations

1. Chen, S., Smith, D. F. Hop as an adaptor in the heat shock protein 70 (Hsp70) and Hsp90 chaperone machinery. J. Biol. Chem. 273: 35194-35200, 1998. 2. Song, Y., Masison, D. C. Independent regulation of Hsp70 and Hsp90 chaperones by Hsp70/Hsp90-organizing protein Sti1 (Hop1) .J. Biol. Chem. 280: 34178-34185, 2005.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

62639 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Stress-induced-phosphoprotein 1

Subcellular Location

Cytoplasm . Nucleus .

Protein Name

Stress-induced-phosphoprotein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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